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Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor <t>digitorum</t> longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative <t>EDL</t> weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
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Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor <t>digitorum</t> longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative <t>EDL</t> weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
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edl muscle  (Dawley Inc)
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Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor <t>digitorum</t> longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative <t>EDL</t> weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
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Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor <t>digitorum</t> longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative <t>EDL</t> weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
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Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor <t>digitorum</t> longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative <t>EDL</t> weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
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Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor <t>digitorum</t> longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative <t>EDL</t> weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
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Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor digitorum longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative EDL weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.

Journal: iScience

Article Title: Directed functional reinnervation to curb nociception and enable sensation

doi: 10.1016/j.isci.2025.114431

Figure Lengend Snippet: Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor digitorum longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative EDL weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.

Article Snippet: Eleven male and two female Sprague-Dawley rats underwent RPNI construction using an extensor digitorum longus (EDL) muscle graft reinnervated by the saphenous neurovascular bundle.

Techniques: Control